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Clemson Falls to SMU 35-24: Tigers Suffer Fourth Loss as Backup QB Struggles at Home

SMU upset Clemson 35-24 at Death Valley as backup QB Christopher Vizzina struggled in his first start. The Mustangs improved to 5-2, while Clemson fell to 3-4.
Dez Barnes Published: October 20, 2025 | Updated: October 20, 2025 5 min read
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Clemson suffered a devastating 35-24 home loss to SMU on October 18, 2025, dropping to 3-4 on the season. Backup quarterback Christopher Vizzina, making his first career start in place of injured Cade Klubnik, showed promise but couldn’t overcome red zone struggles. SMU’s Kevin Jennings threw for multiple touchdowns as the Mustangs improved to 5-2 and remained undefeated in ACC conference play at 3-0. The fourth-quarter collapse at Death Valley included crucial penalties and a controversial pass interference call that sealed Clemson’s fate, potentially ending their College Football Playoff hopes.

Clemson v SMU | Photo Dez Barnes

They say Death Valley is where opponents go to die, but on this October afternoon, it was Clemson’s playoff hopes that took their last breath. Southern Methodist University waltzed into one of college football’s most intimidating venues and left with a gutsy 35-24 victory, handing the Tigers their fourth loss of the season and cementing their status as ACC contenders.

Without star quarterback Cade Klubnik, Clemson turned to redshirt freshman Christopher Vizzina for his first career start. Talk about trial by fire. Vizzina took the field in front of a roaring Death Valley crowd, and while he showed flashes of promise, it wasn’t enough to overcome an SMU team that came prepared for war.

The opening drive looked promising for the young signal-caller. Clemson moved the ball efficiently, giving fans hope that maybe, just maybe, Vizzina could pull off the unthinkable. But the drive stalled, ending in a punt, and the tone was set for what would be a grueling defensive slugfest.

SMU took over near their own two-yard line and struggled just as much. Both offenses looked out of sync, trading punts like heavyweight boxers trading jabs. Then came the moment that could have changed everything—Clemson coughed up a fumble, giving the Mustangs golden field position. But SMU squandered it, proving early that neither team was ready to seize control.

Game day in Death Valley 🐅🏈 The Clemson Tigers look to tame the 4-2 SMU Mustangs in this electrifying ACC matchup!#prettygirlslovesports #collegefootball #clemson #clemsonfootball #smu #acc #sports pic.twitter.com/kM8WXHlxLv

— Dez | Pretty Girls Love Sports (@PGLoveSports) October 18, 2025

Defense ruled the first quarter. Clemson’s defense clamped down on SMU’s run game, forcing quarterback Kevin Jennings to beat them through the air. Meanwhile, Vizzina was still finding his footing, and the Tigers’ offense looked disjointed and tentative.

Then, with less than four minutes left in the opening quarter, Jennings struck. He launched a deep ball into the end zone for a touchdown, giving SMU a 7-0 lead and breathing life into an offense that desperately needed it. The Mustangs had drawn first blood, and Death Valley fell eerily quiet.

Vizzina, to his credit, didn’t flinch. Midway through the second quarter, he connected with TJ Moore for a touchdown, tying the game and giving Clemson fans hope. At 10-7 SMU, it felt like the game was finally settling into a rhythm.

But SMU’s kicker had other plans. The Mustangs tacked on two field goals before halftime—one with 4:29 left and another with just over a minute remaining—to take a 16-7 lead into the break. Both offenses had been anemic, with incomplete passes, stalled drives, and a general lack of energy plaguing both sides. Halftime couldn’t come soon enough.

When the teams returned for the second half, SMU opened with the ball and promptly went three-and-out, mirroring their sluggish start to the game. Clemson got the ball back and finally found some magic. Vizzina, clearly more comfortable now, even brought in third-string QB Denson for a trick play before launching a 65-yard touchdown strike to TJ Moore. Just like that, it was 23-14, and the Tigers were back in it.

But red zone woes continued to haunt Clemson. Late in the third quarter, the Tigers drove deep into SMU territory but settled for a field goal, cutting the lead to 23-17. Vizzina had moved the ball effectively, but the Mustangs’ defense stiffened when it mattered most, keeping Clemson out of the end zone.

The SMU Mustangs are going to UPSET the Clemson Tigers at home in this ACC matchup

— Dez | Pretty Girls Love Sports (@PGLoveSports) October 18, 2025

The fourth quarter was a rollercoaster.

SMU extended their lead with a 22-yard touchdown pass to number 88, but a penalty pushed back the extra point attempt, and the kicker missed it. Instead of a comfortable two-score lead, it was 29-17, and Clemson still had a pulse.

After an injury timeout for lineman number 50 Sabler, the Tigers mounted a comeback drive. Aided by undisciplined SMU penalties, Clemson marched down the field and scored a touchdown, making it 24-29 with 6:44 remaining. Death Valley erupted. The comeback was alive.

SMU got the ball back with under five minutes to play, and the pressure was suffocating. They needed first downs. They needed to control the clock. But their run game, inconsistent all day, wasn’t getting the job done.

Then came the play that broke Clemson’s heart. On fourth-and-seven with under four minutes left, SMU threw incomplete—or so it seemed. But a pass interference call on Clemson gave the Mustangs a first down, and moments later, they punched in the game-sealing touchdown. Final score: 35-24.

The Mustangs celebrated like they’d just won the Super Bowl, and rightfully so. They improved to 5-2 and remained perfect in ACC play. Clemson, meanwhile, dropped to a dismal 3-4, their season in shambles and their playoff dreams all but dead.

For Vizzina, it was a tough learning experience. He showed promise, especially in the second half, but the red zone failures and early jitters cost Clemson dearly. For SMU, this was a signature win—proof that they can compete with anyone, anywhere.

Death Valley may be loud, but on this day, it was the Mustangs who had the last word.

Post game, quote from HC Dabo "Living 2010 all over again, can’t seem to get out of our way but it’s football" On loss to SMU at home #Clemson

— Dez | Pretty Girls Love Sports (@PGLoveSports) October 19, 2025

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Dez Barnes

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